PRIMUS: Prostate Cancer Risk Assessment

1 in 8 men will get prostate cancer

Prostate cancer continues to be the most frequently diagnosed cancer in men, and despite numerous advancements, it remains the second leading cause of cancer-related deaths1. Unhealthy gut microbiota may have a negative impact on your cancer risk.2 Previous research has shown microbiota may cause subtle inflammation starting your colon, leading to immune changes and metabolite production, in turn, influencing your risk of cancer.3,4

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References

  1. Siegel RL , Giaquinto AN , Jemal A . Cancer statistics, 2024. CA Cancer J Clin. 2024; 74(1): 12-49. doi:10.3322/caac.21820
  2. Zitvogel L, Galluzzi L, Viaud S, Vétizou M, Daillère R, Merad M, Kroemer G. Cancer and the gut microbiota: an unexpected link. Sci Transl Med. 2015 Jan 21;7(271):271ps1. doi: 10.1126/scitranslmed.3010473. PMID: 25609166; PMCID: PMC4690201.
  3. Liss MA, White JR, Goros M, Gelfond J, Leach R, Johnson-Pais T, Lai Z, Rourke E, Basler J, Ankerst D, Shah DP. Metabolic Biosynthesis Pathways Identified from Fecal Microbiome Associated with Prostate Cancer. Eur Urol. 2018 Nov;74(5):575-582. doi: 10.1016/j.eururo.2018.06.033. Epub 2018 Jul 12. PMID: 30007819; PMCID: PMC6716160.
  4. Wheeler KM, Liss MA. The Microbiome and Prostate Cancer Risk. Curr Urol Rep. 2019 Sep 7;20(10):66. doi: 10.1007/s11934-019-0922-4. PMID: 31493090.
  5. Bhatt AP, Redinbo MR, Bultman SJ. The role of the microbiome in cancer development and therapy. CA Cancer J Clin. 2017 Jul 8;67(4):326-344. doi: 10.3322/caac.21398. Epub 2017 May 8. PMID: 28481406; PMCID: PMC5530583.
  6. Wu G, Xu T, Zhao N, Lam YY, Ding X, Wei D, Fan J, Shi Y, Li X, Li M, Ji S, Wang X, Fu H, Zhang F, Shi Y, Zhang C, Peng Y, Zhao L. A core microbiome signature as an indicator of health. Cell. 2024 Oct 7:S0092-8674(24)01038-9. doi: 10.1016/j.cell.2024.09.019. Epub ahead of print. PMID: 39378879.
  7. Sosnowski K, Akarapipad P, Yoon J-Y. The future of microbiome analysis: Biosensor methods for big data collection and clinical diagnostics. Med Devices Sens. 2020; 3:e10085. https://doi.org/10.1002/mds3.10085